정보

• 소속 : 약리학교실
• 직위 : 교수
• 전공 : 약리학
• 세부전공 : 임상약리학
• 연락처 : 02 2258 7327
• 이메일 : yimds@catholic.ac.kr

논문

• Usefulness of Bnet, a Simple Linear Metric in Discerning Torsades De Pointes Risks in 28 CiPA Drugs, FRONTIERS IN PHARMACOLOGY, 201911
• Three-Dimensional Heart Model-Based Screening of Proarrhythmic Potential by in silico Simulation of Action Potential and Electrocardiograms, FRONTIERS IN PHYSIOLOGY, 201909
• Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP), PHARMACEUTICS, 201907
• Potency and plasma protein binding of drugs in vitro-a potentially misleading pair for predicting in vivo efficacious concentrations in humans, KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 201907
• Application of Pharmacometrics in Pharmacotherapy: Open-Source Software for Vancomycin Therapeutic Drug Management, PHARMACEUTICS, 201905
• Five years of the CiPA project (2013-2018): what did we learn?, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201812
• Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 201708
• Bortezomib pharmacokinetics in tumor response and peripheral neuropathy in multiple myeloma patients receiving bortezomib-containing therapy, ANTI-CANCER DRUGS, 201707
• Drug-drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer, DRUG DESIGN DEVELOPMENT AND THERAPY, 201705
• Use of a Target-Mediated Drug Disposition Model to Predict the Human Pharmacokinetics and Target Occupancy of GC1118, an Anti-epidermal Growth Factor Receptor Antibody, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 201703
• Comparison of oral absorption models for pregabalin: usefulness of transit compartment model, DRUG DESIGN DEVELOPMENT AND THERAPY, 201612
• Immunogenicity and safety of trivalent split influenza vaccine in healthy Korean adults with low pre-existing antibody levels: An open phase I trial, YONSEI MEDICAL JOURNAL, 201611
• Therapeutic drug monitoring and safety of intravenous voriconazole formulated with sulfobutylether β-cyclodextrin in haematological patients with renal impairment, MYCOSES, 201610
• Revisiting the well-stirred model of hepatic clearance: QH, CLH and F changing in the same direction, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201609
• Tips for the choice of initial estimates in NONMEM, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201609
• Population pharmacokinetics of imatinib mesylate in healthy Korean subjects, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201606
• Problems within the post-marketing surveillance system in Korea: Time for a change, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201606
• Volume of Distribution, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201606
• Population pharmacokinetics and inter-laboratory variability of sildenafil and its metabolite after oral administration in Korean healthy male volunteers, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201606
• Simulation of PET scan timings for receptor occupancy studies of CNS drugs: a simple fixed-time design performed as well as scattered time point designs, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 201511
• Model-based adaptive phase I trial design of post-transplant decitabine maintenance in myelodysplastic syndrome, JOURNAL OF HEMATOLOGY & ONCOLOGY, 201510
• Exposure-response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development, DRUG DESIGN DEVELOPMENT AND THERAPY, 201509
• SAFETY OF A CRM197-CONJUGATED HAEMOPHILUS INFLUENZAE TYPE B VACCINE IN KOREAN CHILDREN, SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, 201507
• Statistical basis for pharmacometrics: maximum likelihood estimator and its asymptotics, TRANSLATIONAL AND CLINICAL PHARMACOLOGY(구.임상약리학회지), 201506
• Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects, DRUG DESIGN DEVELOPMENT AND THERAPY, 201502
• Serotonin transporter occupancy of SKL10406 in humans: comparison of pharmacokineticpharmacodynamic modeling methods for estimation of occupancy parameters, 임상약리학회지, 201412
• Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients, DRUG DESIGN DEVELOPMENT AND THERAPY, 201411
• Population Pharmacokinetic Analysis of Piperacillin in Burn Patients, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 201407
• The effects of moxifloxacin on QTc interval in healthy Korean male subjects, DRUGS IN R&D, 201406
• Modeling of the Parathyroid Hormone Response after Calcium Intake in Healthy Subjects, KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 201406
• Overestimation of Vancomycin Clearance by the Linear Regression Formula in Rodvold’s Report: Why?, INFECTION AND CHEMOTHERAPY (구.감염과 화학요법), 201403
• 건강한 성인 남성을 대상으로 Levodropropizine CR정반복 투여시의 약동학적 특성 및 안전성에 관한 연구, 임상약리학회지, 201312
• Saturable human neopterin response to interferon-alpha assessed by a pharmacokinetic-pharmacodynamic model, JOURNAL OF TRANSLATIONAL MEDICINE, 201310
• 건강한 남성 자원자에서 실데나필 제제인 플리즈구강용해필름과 비아그라 약동학적 특성 및 안전성의 비교평가, 임상약리학회지, 201306
• Population Pharmacokinetic Analysis of Fluconazole To Predict Therapeutic Outcome in Burn Patients with Candida Infection, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 201302
• Pharmacokinetic-pharmacodynamic model of fimasartan applied to predict the influence of a high fat diet on its blood pressure-lowering effect in healthy subjects, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 201301
• The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects, KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 201208
• Phase 1 trial of S-1 in combination with sorafenib for patients with advanced hepatocellular carcinoma, INVESTIGATIONAL NEW DRUGS, 201208
• Population Pharmacokinetic/Pharmacodynamic Modeling of Clopidogrel in Korean Healthy Volunteers and Stroke Patients, JOURNAL OF CLINICAL PHARMACOLOGY, 201207
• MIXED-EFFECT CIRCADIAN RHYTHM MODEL FOR HUMAN ERYTHROCYTE ACETYLCHOLINESTERASE ACTIVITY - APPLICATION TO THE PROOF OF CONCEPT OF CHOLINESTERASE INHIBITION BY ACORN EXTRACT IN HEALTHY SUBJECTS WITH GALANTAMINE AS POSITIVE CONTROL., EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 201205
• Randomised phase II trial of docetaxel and sunitinib in patients with metastatic gastric cancer who were previously treated with fluoropyrimidine and platinum, BRITISH JOURNAL OF CANCER, 201204
• Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 201204

저서

• 계량약리학 워크샵 초급과정, 부크크, 202007